Male Breast Cancer

Breast cancer depends on the type by how it is initiated i.e. in the lobules or ducts. As per the study reveals 15% of breast cancer is accounted by medullary carcinoma. Actually on can define breast cancer as a cancer which forms in the tissues of the breast which comprises mainly of ducts (these are the tubes which carry milk towards the nipple) and lobules (glands that produce milk).this cancer can be found in both types of gender i.e. in male and female. However, a case of male breast cancer is found quite rare. Below are illustrated some common symptoms of breast cancer.

Symptoms:

If one acknowledges the symptoms of a particular disease at the initial stages, then its cure becomes quite easy and hence it saves life. The treatment options are enhanced as chances of survival increases. It is usually carried by a thickening of lump in the armpit or breast. There may be an inadequate change in the shape and size of the breast.

The nipple is discharged. The texture and color of skin around the areola (dimpling and puckering) changes. The main concern comes when there is frequent flow of blood from the breasts. However in almost every case one must try to evacuate the breast discharge. Certain change in the nipple shape and there are cases when the nipple sinks in to the breast and hence there is regularity in its shape. A frequent discharge of blood stain from the nipple. There are subsequent rashes and on the nipple and its surrounding area.

Causes:

Age: Age is an important factor in determining the risks of breast cancer as a woman gets older the chances of occurring of breast cancer increases. Generally women who are above 60 years of age are highly affected by breast cancer. Personal history: A woman who is already suffering from breast cancer in her single breast has increased chances of developing the same in the other breast as well. Almost 12.5% of women ranging between age limits around 45 show positive results in breast cancer diagnoses, however in case of women older than 55 the chances increase and are around 66.7% approximately.

Treatments:

Surgery: Here the important aspect lies on removing the cancerous tissues by analyzing it by its hormonal status, size, grade and possible metastasis.

Talk about breast cancer and naturally, people think of the disease that is the number one cancer among women. But the truth is that breast cancer is on the rise among both women and men, and researchers think the national obesity crisis may be to blame.

With two-thirds of Americans now overweight, we can probably expect more obesity-related cancers. But on the brighter side, weight problems are extremely treatable, even preventable. So to the extent overweight is contributing to cancer, this is one risk factor we may actually have some real control over.

Just how we go about getting that control appears to be critical, though. Even among the most motivated of people, we see that very few are successful in independent efforts to lose weight, even if their life depends on it. And among cancer patients, it clearly does.

Consider some of the numbers: breast cancer in women increased by 52 percent from 1973 to 1998. Part of that increase can be accounted for by better detection, because mammography is much more available than it was 30 years ago. But use of post-menopausal estrogen supplements has also become routine, and these have been clearly linked to cancer in women.

But in that same period, incidence of breast cancer among men increased by 26 percent, and that’s without the ingested estrogen and without the extra detection offered by mammography, since men typically don’t pursue that procedure.

So what else is going on? Experts say the increase in breast cancer in both sexes seems to closely track the increase in American obesity, giving rise to the theory that the obesity crisis may actually be to blame for the boom in breast cancer.

Obesity has been shown to have a clear relationship with some cancers, but not with others. For instance, there does not appear to be any correlation between overweight and prostate cancer in men. Or sometimes, the relation is clear, but the reasons aren’t. Hence, researchers are looking at whether acid reflux in overweight people might account for their greater incidence of esophogeal cancer.

But with breast cancer, there is at least one known culprit: all that excess estrogen. Fatty tissue produces estrogen, in both men and women.

Studies of menopausal women make the case most clearly. Before menopause, the ovaries are the primary source of estrogen. But after menopause, when the ovaries have retired from that duty, fatty tissues are the main estrogen source.

Among postmenopausal women, estrogen levels are 50 to 100 percent higher in heavy women, compared to those of healthy weight. Similar ratios are found among men.

And when estrogen-sensitive tissues get more estrogen exposure, that leads to more growth of estrogen-responsive breast tumors.

Researchers figure that between 11,000 and 18,000 breast cancer deaths per year could be avoided in American women over age 50, if they could maintain a healthy body weight throughout their adult lives. There are no similar guesstimates for men, because while breast cancer is a growing problem for men, there is little research on mortality rates among males, and it is still less of a concern than heart disease or prostate and colon cancer.

But obesity puts men at higher risk for these diseases, as well, so the imperative is to drop that excess weight, or at least some of it. There’s abundant evidence that even a minor weight loss reaps huge rewards for health. So how do you do it?

It’s tough, especially if you’re an older person, and the average age of diagnosis for breast cancer is 62 among women, and 67 among men.

Motivation counts, but the research shows that it’s not enough. People need help. For instance, who would be more motivated to lose weight than a heavy person who had already survived cancer?

An overweight survivor has a double whammy when it comes to risk of recurrence, but a study published earlier this year in Obesity Research said that even among that motivated group, people left to their own devices, or those who only had a group program did not achieve much weight loss.

This is no surprise to those of us who have treated obesity for years. We see people who have tried diet after diet, joined gym and club and fellowship alike, all to no avail. But when they are treated with a comprehensive diet and lifestyle modification program that has been designed specifically for them, things change.

In this latest study, the researchers were pretty unequivocal, concluding that “for breast cancer survivors to lose weight to reduce risk factors, intervention is necessary. Of the different intervention regimens, individualized counseling combined with attending weekly … meetings was most effective….”

When you’re facing a chocolate éclair, death is perhaps too abstract an idea, even if you’ve only narrowly escaped it. Without some real retraining, it’s hard to equate even the greasiest burger with a lethal tumor. But professional support makes all the difference.

For instance, I’ve been tracking insulin levels in weight management patients for years, because we know that high insulin levels indicate a metabolic abnormality that leads to diabetes and weight gain. Now recent research shows that elevated insulin levels are also a risk factor for breast cancer recurrence.

Yet very specific changes in lifestyle and diet can significantly reduce insulin levels in days to weeks, immediately reducing those disease risks. The disembodied threat of disease is sometimes hard for people to get their arms around, but when patients can look at their lab results and see how their behavioral changes directly affect their blood chemistry, it hits home.

What happens to patients’ bodies on the inside as they lose weight is more important than the changes they get on the outside, but even at the best health clubs or peer support groups, they won’t have an opportunity to see that.

It’s inspiring to see how people embrace a fitness and weight-loss program when they have more than just a bathroom scale to tell them that it’s working. Consistent and reliable guidance is essential because nobody goes from obese to healthy overnight. It takes time.

But cancer takes time, too, so the race is on. With the proper help, this is a race both men and women have great odds of winning.

Breast cancer is a growing risk for both men and women, and it’s a cancer for which the obesity link has been clearly established. Fat produces excess estrogen; excess estrogen produces breast cancer. And in the reverse, weight loss reduces cancer risk. The data are clear, but it doesn’t make the task any easier. What does make it easier, and more successful, is professional help-—-and the sooner the better.

Genetic test which is also known as DNA-based test is the most powerful technique used to test for breast cancer detection. It involves the direct examination of DNA molecule itself. By using a molecular diagnostic test to assess whether a breast tumor will respond to chemotherapy, doctor’s need to more precisely identify which patients can be adequately treated with hormonal therapy alone and which patients will truly benefit if chemotherapy is added to the treatment. With better individualized treatment, we can spare  the side effects of chemotherapy where it is unnecessary. Breast cancer, like other cancers, develops when changes occur in genes in breast cells. In that sense, all breast cancer has a genetic element. But, “genetic” does not mean inherited. Only an estimated 5% to 10% of breast cancer cases result from an inherited genetic predisposition to the disease. In other words, more than 90% of all breast cancer cases result from factors that are not inherited and, in many cases, are unknown.

So far, researchers have found two genes linked with breast cancer-labeled BRCA1 and BRCA2-that everyone inherits in pairs: one from our mother and one from our father. When they function normally, they are supposed to stop the growth of cancerous cells in the breast. When both genes in a pair are damaged, they don’t work properly and cancer may develop. People who inherit a damaged BRCA1 or BRCA2 gene from one parent are at greater risk of developing breast cancer than people who inherit two normal genes.

Studies can estimate risk among large numbers of people who have an inherited mutation, but not the risk for an individual .

By being able to identify these genes through particular markers associated with the gene, doctors will know which individuals are more susceptible to cancer and therefore can follow the proper procedure. The earlier the doctor can diagnose the cancer, the more effective the treatment will be. Scientists warn however that, although they have discovered one of the genes associated with breast cancer, there is still no cure available. They have successfully identified the gene, but presently there is no way to “repair” the gene. The recent isolation of the gene BRCA-1 has prompted investigators to identify other genes that may contribute to breast cancer.

Breast cancer is the most common cancer and the second leading cause of cancer deaths in women in the United States.  In 2008, approximately 184,450 patients were estimated to be diagnosed with invasive breast cancer, and an estimated 40,930 were estimated to die of this disease.   Furthermore, over 50,000 female carcinoma in situ breast cases would have been diagnosed.  The etiology of breast cancer is poorly understood with multiple genetic and environmental factors involved in the initiation and progression of cancer. 

Scandinavian Twin Study: For years, there has been a hot debate as to whether the cause of breast cancer is genetic or environmental.  Then in 2000, Lichtenstein and his colleagues at the Karolinska Institute in Sweden published their study of 44,788 pairs of twins from the Swedish, Danish, and Finnish twin registries.  In this study, they looked at cancer risk with 28 different types of cancers and did statistical modeling of genetic and hereditary contributions in eleven different cancer types.  For breast cancer, they clearly showed that only 27% of breast cancers were due to genetic factors.  This was an even lower hereditary component than other common cancers such as prostate and colorectal.  This study and others have confirmed the fact that over 70% of breast cancers are influenced by environmental factors.

BRCA genes: Although much attention has been made about hereditary breast cancer, only two genes are commonly tested for breast cancer risk assessment.  These two genes are tumor suppressor genes named “BRCA1″ and “BRCA2″ that are involved with DNA repair.  These two genes only account for about 5% of all breast cancers.  Because of the Scandinavian twin study, most experts believed that there are other yet to be discovered genes involved with breast cancer.  Because the chance of having a BRCA mutation in the general population is so low, genetic testing is not indicated in most patients.  However, if a patient has a family history of breast cancer, then a mathematical model can be used to determine if BRCA testing is indicated.  The likelihood of being a BRCA carrier increases with the number of relatives who had cancer and if the cancers occurred earlier in life.  For example, in families with four or more cases of breast or ovarian cancer under the age of 60, over 80% are found to have a damaged version of BRCA1 or BRCA2.  If a patient is a carrier of one or both of the BRCA1 and BRCA2 genes, her risk of breast cancer dramatically increases.  According to estimates of lifetime risk, about 13.2% (132 out of 1,000 individuals) of women in the general population will develop breast cancer, compared with estimates of 36-85% (360-850 out of 1,000) of women with an altered BRCA1 or BRCA2 gene.  In other words, women with an altered BRCA1 and/or BRCA2 gene are up to eight times more likely to develop breast cancer than women without alterations in those genes.  The BRCA1 mutation confers a higher risk than a BRCA2 mutation.  Women who inherit a damaged BRCA1 gene have a 60-85% chance of developing breast cancer at some stage in their lives and a 20-40% chance of developing ovarian cancer.  For BRCA2, the risks are 40-60% and 10-20%, respectively.

Family History and Breast Cancer: Although the spotlight in hereditary breast cancer has been directed on the BRCA genes, the majority of patients with a family history of breast cancer are BRCA1 and BRCA2 negative.  Even in these BRCA negative patients, however, there is an increased risk of developing cancer with a family history of breast cancer.   Six factors (unrelated to BRCA genes) have been studied in patients with a family history of breast cancer.  They are as follows:

1.  Degree of relationship:  If the family member with a history of cancer is a first degree relative, the increased risk is much greater than for second degree relatives.

2.  Number of relatives who have had breast cancer:  People with two or more family members who have had breast cancer are at higher risk than those with only one affected relative.

3.  Age of onset of cancer:  If the relative developed breast cancer at an early age (pre-menopausal), the risk is higher than if the relative developed post menopausal breast cancer.

4.  Bilateral breast cancer:  If the relative has a history of bilateral breast cancer, the risk is greater than having a relative with unilateral breast cancer.

5.  Gender of the relative:  If the family member with breast cancer is a man, the risk is higher.

6.  Other related early onset tumors:  If there is a family history of early onset ovarian cancer, this incurs an increased risk for a person.

How to decide whether you need the BRCA gene test

The following is an excerpt from the American Society of Breast Surgeons:

1.  Early onset breast cancer (diagnosed before age 50)

2.  Two primary breast cancers, either bilateral or ipsilateral

3.  A family history of early onset breast cancer

4.  Male breast cancer

5.  A personal or family history of ovarian cancer

6.  Ashkenazi (Eastern European) Jewish heritage

7.  A previously identified BRCA1 or BRCA2 mutation in the family

Any one of these features alone indicates a risk for harboring a BRCA1 or BRCA2 mutation.  The presence of more than one of these features raises that risk to greater than 10%, the traditional cutoff for recommending a BRCA test. Such patients should have access to BRCA testing.  A simple risk-calculation model based on the prevalence of mutations seen among women tested for BRCA mutations is available at http://www.brcacalculator.com.

Breast cancer is a cancer of the glandular breast tissue. Breast cancer affects one in eight women during their lives. Breast cancer may be one of the oldest known forms of cancer tumors in humans. Breast cancer kills more women in the United States than any cancer except lung cancer. Breast cancer is the most common cause of cancer in women and the second most common cause of cancer death in women in the U.S. While the majority of new breast cancers are diagnosed as a result of an abnormality seen on a mammogram, a lump or change in consistency of the breast tissue can also be a warning sign of the disease. Breast cancer is the most common cause of death in women between the ages of 45 and 55. Although breast cancer in women is a common form of cancer, male breast cancer does occur and accounts for about 1% of all cancer deaths in men. Breast cancer usually begins with the formation of a small, confined tumor. Some tumors are benign, meaning they do not invade other tissue; others are malignant, or cancerous. Malignant tumors have the potential to metastasize, or spread. Some risk factors, such as your age, and family history, can’t be changed, whereas others, including weight, smoking and a poor diet, are under your control.

A woman’s risk of breast cancer is higher mother, sister, or daughter had breast cancer. The risk can actually be lower if you have a short menstrual life, large family or first child before age 18 years. Men have a lower risk of developing breast cancer (approximately 1.08 per 100,000 men per year), but this risk appears to be rising. Other risks include being overweight, using hormone replacement therapy, taking birth control pills, drinking alcohol, not having children or having your first child after age 35 or having dense breasts. Alcohol appears to increase the risk of breast cancer, though meaningful increases are limited to higher alcohol intake levels. Breast cancer constitutes about 7.3% of all cancers. Symptoms of breast cancer may include a lump in the breast, a change in size or shape of the breast or discharge from a nipple. Most breast lumps are benign , that is, they are not cancer. Benign breast tumors are abnormal growths, but they do not spread outside of the breast and they are not life threatening.

Treatment of breast cancer include Radiation Therapy, Chemotherapy, Hormone Therapy, and Immune Therapy. Certain foods, vitamins, or minerals may interfere with cancer treatment. Drink plenty of fluids but avoid drinks during meals because they may cause a bloated feeling. Proteins: May provide protein, iron, zinc, and B vitamins. Meats, beans, nuts, and seeds provide these benefits. Some seeds, like almonds, are good sources of vitamin E. Dairy products: Milk and cheese provide calcium, protein, and vitamin B12. Grains: Breads, pasta, rice, and cereals provide carbohydrates and B vitamins. Carbohydrates are an important source of energy. Eat cruciferous vegetables, such as broccoli, bok choy, and brussel sprouts – which contain plant phytochemicals that lower blood estrogen levels by increasing the estrogen detoxification capacity of the liver. Try cool foods. Warm foods may worsen nausea. Do not eat or drink until vomiting is under control.

Breast Cancer Treatrment and Diet Tips

1.Eat a diet lower in fat, ideally no more than 18% of your daily caloric intake.

2. Use “good” fats — monounsaturated and omega-3 fats – from olive oil, flax seed oil, almond oil and canola oil, as well as fats from deep-sea fish.

3. Eat cruciferous vegetables, such as broccoli, bok choy, and brussel sprouts.

4. Eat a diet high in fiber, with plant-based sources of protein.

5. Soy, aim for 1 to 2 servings of soy products per day.

6. Tea (black or green), aim for 3 to 5 servings per day.

7. Nitrates and nitrites, avoid cured meats when possible.

8. Carbohydrates are an important source of energy.